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Item No.
10194-1
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm Rx
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One-time purchase
$112.99
Product Description
Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste is the first treatment approved by the FDA for equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona. EPM is a serious neurologic disease that can lead to muscle loss, ataxia, and incoordination if untreated. The active ingredient, ponazuril, is a triazine-class antiprotozoal that crosses the blood-brain barrier to kill parasites in the central nervous system and prevents further neurologic damage. The easy-to-use oral paste comes in a calibrated syringe for accurate dosing and features a loading-dose and maintenance protocol that allows for rapid therapeutic levels. When used as directed, Marquis provides safe and effective parasite clearance in four weeks.
Who is Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm for?
Horses
Why use Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm?
• For treatment approved by the FDA of EPM in horses
• Ponazuril crosses the blood-brain barrier to act directly on CNS parasites
• Convenient oral paste delivery, with calibrated dosing syringe for accuracy
• Proven efficacy in field studies and clinical trials
• Safe when used as directed
How does Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm work?
Marquis contains ponazuril, a triazine-class antiprotozoal that targets the merozoite stages of Sarcocystis neurona. The compound interferes with protozoal metabolic pathways leading to parasite death. Because it crosses the blood-brain barrier, it can act within the central nervous system to reduce further damage.
Manufacturer:
Boehringer Ingelheim
Active Ingredients(s):
Ponazuril (15% w/w) per gram of oral paste.
How is Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm sold?
Sold as individual 127 gram tube
What are the side effects of Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm?
Possible Side Effects :
• Loose feces (diarrhea) have been reported.
• Mild colic, inappetence, hives, or blisters on lips/muzzle in some horses. US-EQU-0397-2025
• Neurologic signs may temporarily worsen early in treatment before improving.
• In toxicity studies: loose feces, weight loss, occasional histopathologic changes in the uterine epithelium edema at high multiples.
What special precautions are there?
Warnings:
• Administer only to horses.
• The safety in pregnant, lactating mares or breeding horses is unknown.
• Neurologic signs (e.g. ataxia) may transiently worsen early during therapy, typically resolving over time.
• Distinguish EPM from other neurologic, orthopedic, or systemic causes before treatment.
US-EQU-0397-2025
• At the end of the prescribed treatment period, partially used syringes should be discarded.
Caution/Precautions:
• Horses may experience loose stools, mild colic, or inappetence, oral ulcers or hives during treatment.
• Neurologic signs may temporarily intensify as parasites die off; monitor closely and contact a veterinarian if symptoms worsen significantly.
• Use only under veterinary supervision.
• Do not administer to horses with known hypersensitivity to ponazuril or other triazine compounds.
• The safety of concurrent use with other antiparasitic or neurologic medications has not been evaluated.
What to do if overdose?
Contact your nearest emergency animal hospital.
How can I store Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste for Horses, 127 gm?
Store at 15–30 °C (59–86 °F). Excursions permitted within this range. Do not freeze. Protect from direct sunlight and keep the syringe cap tightly closed when not in use. Use entire contents within the treatment course period; discard partially used syringes per veterinary disposal guidelines.
Overview
Dosage Instructions/Directions:
• On Day 1, a loading dose of 15 mg/kg (6.8 mg/lb) (three times the maintenance dose) is recommended to quickly reach effective concentrations.
• After day 1, administer orally at a dose of 5 mg/kg body weight (2.27 mg/lb) once daily for 28 days.
• Each full syringe treats a 1,200 lb (545 kg) horse at the maintenance dose.
• Use the calibrated weight-markings on the syringe plunger to ensure accurate dosing.
• Make sure the horse’s mouth is free of feed before administration.
• Insert the syringe tip into the mouth at the interdental space and deposit the paste on the back of the tongue.
• Raise the horse’s head briefly to ensure swallowing.
• Complete the full 28-day course unless otherwise directed by a veterinarian.
Main Ingredients
Active Ingredients : Ponazuril (15% w/w) per gram of oral paste.