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Credelio Quattro / Credelio Quattro-CA1 Flavored Chewable Tablet for Dogs & Puppies Rx

By Credelio
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Product Description
Credelio Quattro / Credelio Quattro-CA1 (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) offers the broadest parasite coverage of its kind*, targeting 7 types of parasites§ in one flavored chewable tablet. It covers ticks, fleas, heartworm disease, New World screwworm larvae, and three intestinal worms that can be passed to humans: roundworms, hookworms, and tapeworms.

Along with broader parasite coverage than other chewable brands of its kind*, Credelio Quattro works fast where it counts. Thanks to lotilaner, one of the four active ingredients, it kills >99% of fleas within 8 hours of administration and remains effective for an entire month [3].

Crafted for sensitive dogs, Credelio Quattro / Credelio Quattro-CA1 comes in a tasty beef-flavored chewable that's meat allergen-free [9]. It's easy to give –– with successful administration to 98% of dogs in a U.S. field study [1] –– and easy to fit into your dog's routine. Best of all, Credelio Quattro / Credelio Quattro-CA1 can be prescribed to dogs and puppies at least 8 weeks old and weighing at least 3.3 lbs. Your veterinarian will prescribe the right dose for your dog.

*Based on label comparison of the number of parasite types covered in a chewable that targets ticks.

§Credelio Quattro protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms, and tapeworms. Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness.

[1] Elanco Animal Health. Data on file. REF-29599
[3] Cavalleri D et al. Parasit Vectors 2017;10(1):529
[9] Elanco Animal Health. Data on file. REF-26775

Who is Credelio Quattro / Credelio Quattro-CA1 Flavored Chewable Tablet for Dogs & Puppies for?
Dogs and Puppies (8 weeks of age or older and weighing at least 3.3 lbs)
Why use Credelio Quattro / Credelio Quattro-CA1 Flavored Chewable Tablet for Dogs & Puppies?
• 7-IN-1 PARASITE COVERAGE: Credelio Quattro / Credelio Quattro-CA1 helps bring peace of mind with the broadest parasite coverage of its kind available to dogs, targeting 7 types of parasites in one chewable tablet. • COVERS MORE THAN FLEAS & TICKS: This flea and tick treatment is the first and only chewable for dogs that covers ticks, fleas, heartworm disease, New World screwworm larvae, and 3 intestinal worms that can be passed to humans — roundworms, hookworms and tapeworms. • KILLS TICKS & FLEAS FAST: This tick and flea chewable begins to kill ticks and fleas within 4 hours, so there can be one less thing to come between you and your pet. • TASTY & EASY TO GIVE: This FDA-approved parasite coverage comes in a flavored chewable tablet, with successful administration to 98% of dogs in a U.S. field study. • Credelio Quattro / Credelio Quattro-CA1 protects dogs against ticks, fleas, heartworm disease, roundworms, hookworms, and tapeworms. Credelio Quattro-CA1 is conditionally approved for the treatment of New World screwworm larvae infestations in dogs pending a full demonstration of effectiveness.
How does Credelio Quattro / Credelio Quattro-CA1 Flavored Chewable Tablet for Dogs & Puppies work?
Credelio Quattro/Credelio Quattro-CA1 contains four active pharmaceutical ingredients, lotilaner, moxidectin, praziquantel, and pyrantel (as pamoate salt). Lotilaner is an ectoparasiticide belonging to the isoxazoline group. Lotilaner inhibits insect and acarine gamma-aminobutyric acid (GABA)-gated chloride channels. This inhibition blocks the transfer of chloride ions across cell membranes, which results in uncontrolled neuromuscular activity leading to death of insects and acarines. The selective toxicity of lotilaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines' GABA receptors versus mammalian GABA receptors. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Praziquantel's mode of action is not precisely known, but treated tapeworms undergo muscular paralysis accompanied by a rapid influx of calcium ions and the disruption of the tegument. Pyrantel is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, causing paralysis and death or expulsion of the parasite.
Manufacturer:
Elanco
Active Ingredients(s):
Lotilaner, Moxidectin, Praziquantel, and Pyrantel
How is Credelio Quattro / Credelio Quattro-CA1 Flavored Chewable Tablet for Dogs & Puppies sold?
Sold in 1 count / 1 month supply or 6 count / 6 month supply for the following dog sizes : 3.3-6 lbs Yellow, 6.1-12 lbs Pink, 12.1-25 lbs Orange, 25.1-50 lbs Green, 51-100 lbs Blue.
What are the side effects of Credelio Quattro / Credelio Quattro-CA1 Flavored Chewable Tablet for Dogs & Puppies?
Possible side effects may include : diarrhea, vomiting, lethargy, anorexia, dermatitis, weight loss, itching or alopecia.
What special precautions are there?
Not for use in humans. Keep this and all drugs out of reach of children. Wash hands after handling. If accidentally ingested, seek medical attention immediately. Keep Credelio Quattro in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose. Lotilane one of the ingredients in Credelio Quattro is a member of the Isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving Isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Prior to use, dogs should be tested for existing heartworm infections and treated at the discretion of your veterinarian. Administer orally once monthly and with food.
What to do if overdose?
Contact your nearest emergency animal hospital
How can I store Credelio Quattro / Credelio Quattro-CA1 Flavored Chewable Tablet for Dogs & Puppies?
Store at 15-25 °C (59-77 °F). Excursions permitted between 5 and 40 °C (41 and 104 °F).
Overview
Use as directed by your Veterinarian.

Dosage and Administration:
Credelio Quattro / Credelio Quattro-CA1 is given orally once a month, at the minimum dosage of 9mg/lb (20mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5mg/kg) praziquantel and 2.28 mg/lb (5mg/kg) pyrantel )as pamoate salt). Quattro must be administered with food. Care should be taken to ensure that the dog consumes the complete dose. If vomiting occurs within an hour after administration, readminister a new dose. If a dose is missed, give Credelio Quattro / Credelio Quattro-CA1 immediately and resume a monthly dosing schedule.   

Body Weight / Tablets to Administer / Lotilaner per Tab (mg) / Moxidectin per Tab (mg) / Praziquantel per Tab (mg) / Pyrantel per Tab (mg)
3.3-6lbs         /              1                   /              56.25                /              0.056                    /                  14.25                 /              14.25
6.1-12           /               1                   /             112.5                 /              0.113                    /                   28.5                  /              28.5
12.1-25         /              1                   /               225                   /              0.225                   /                    57                    /               57 
25.1-50         /               1                  /              450                   /                .45                      /                   114                   /               114
50.1-100       /               1                  /              900                   /                .9                        /                    228                  /               228
> 100   Administer the appropriate combination of tablets

Prior to use, dogs should be tested for existing heartworm infections and treated at the discretion of your veterinarian. Administer orally once monthly and with food.
Main Ingredients
Lotilaner, Moxidectin, Praziquantel, and Pyrantel

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